TITAN - Ocular Toxoplasmosis is the continuation of the first TITAN - Viral Anterior Uveitis. The current management of ocular toxoplasmosis still lacks international consensus on the investigation and diagnosis to initiate treatment and treatment approach for such patients. As a result, the ophthalmic fraternity still is unable to answer the question - How best do I manage a patient with ocular toxoplasmosis?

TITAN - Ocular Toxoplasmosis aims to establish treatment algorithms for the management of ocular toxoplasmosis through extensive literature review and collation of expert opinions from around the world.


A literature synthesis of the current research into ocular toxoplasmosis was performed and from there key questions and assumptions regarding the management of ocular toxoplasmosis were collated and formatted into the first online questionnaire (Delphi round one) by the core and steering committee of TITAN.

The level of evidence (LoE) for the literature synthesis was graded using the Oxford Centre for Evidence-Based Medicine levels of evidence criteria and provided as a pre-reading within the questionnaire for invited respondents to reference.

Following statistical analysis of the results, those statements with <70% consensus will be consolidated for further scientific deliberation using an online videoconferencing platform before administering a second and final refined questionnaire. Whenever possible, the second round of the survey will be held during face-to-face meeting. It is hoped through this iterative process we can achieve consensus on the management of ocular toxoplasmosis amongst the invited international uveitis experts and subsequently publish guidelines in the managing ocular toxoplasmosis for the wider ophthalmic community.


This follow-up survey will take approximately 30 minutes to complete. It is optimized for desktop and mobile devices with at least a 10” screen. You will first have to review the current literature on the management of ocular toxoplasmosis provided before attempting the survey proper. Your responses will be automatically saved and you can complete the survey over multiple sessions.

Note: The survey is to be submitted via the personalized encrypted electronic link provided to you should you agree to participate.

If you have any questions about this study, please kindly forward your inquiries to us.

For Technical Assistance please contact: 

Dr Rupesh Agrawal
Associate Professor and Senior Consultant
Department of Ophthalmology
National Healthcare Group Eye Institute
Tan Tock Seng Hospital
Singapore 308433
Email: rupesh_agrawal@ttsh.com.sg
Dr Ikhwanuliman Putera
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia
Cipto Mangunkusumo Kirana Eye Hospital,
Jakarta, Indonesia 10320
Email: ikhwanuliman.putera81@ui.ac.id

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